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[61] [62] Prognosis [edit] Long-term studies in gastroparesis patients show that it is not a benign disease and has significant morbidity and a poor prognosis due to the limited options for treatment

Its involvement in fatty acid metabolism may help support healthy lipid metabolism and energy production in heart tissue

2,20 Antifibrotic Effects GLP-1RAs downregulate transforming growth factor- signalling pathways in myocardial fibrosis

Sci Signal 2012

Semaglutide is generally not advised for people with a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2, among others

A 2022 review reported that no adverse side effects in humans have been detected yet