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Musculoskeletal pain may respond well to anti-inflammatory medications, physical therapy, and avoiding activities that exacerbate pain

This sudden shift affects mood, energy, sleep quality, and, critically, metabolic rate

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CJC-1295 extends the GH release window beyond what ipamorelin alone provides, creating sustained overnight GH elevation that supports fat oxidation, muscle protein synthesis, and deep sleep

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The randomized, double-blind, placebo-controlled trial by Depommier et al., 2019 demonstrates low risk of bias overall, with clearly defined eligibility criteria, intervention protocols, and prespecified outcomes