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they may originate from mature melanocytes residing in the basal cell layer of the epithelium that have undergone some cytogenetic alterations culminating in their dedifferentiation into naevomelanocytes or they may originate from stem/progenitor melanocytes that have undergone cytogenetic alteration in the process of replacing mature melanocytes in the epithelium lost to mechanical, thermal, or chemical injury or as a result of apoptotic processes

Meeting the clinical criteria is the first step

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They play roles in collagen synthesis, cellular regeneration, and reducing inflammation

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The injection is the only form currently FDA-approved to treat MASH, but your doctor may prescribe the oral form to support weight loss