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B12 deficiency can lead to several health issues, which include anemia characterized by fatigue, and weakness
Published human data are limited and consist mainly of pilot studies and retrospective observations
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The oxidative stress allied with the increased endogenous ROS like superoxide anion (O 2 ) , hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH ) are mainly generated either due to mitochondria dysfunction or by the activation of the various enzyme oxidases including NADPH oxidase, P450 mono-oxygenase, cyclooxygenase, indolediamine dioxygenase, xanthine oxidase, and the Rho kinases (Kirkham and Rahman 2006)
To investigate whether GHEA can produce oxygen under laser irradiation at an intensity of 0.5 W/cm 2 , GHEA and GHEA@Gel were subjected to 658 nm laser irradiation at an intensity of 0.5 W/cm 2 , and the changes in oxygen availability in the system were measured every 2 min for a total duration of 30 min
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