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Although metformin increased GLP-1R level, exendin (939) or GLP-1R siRNA did not attenuate the protective effects of metformin in PA-impaired HUVECs, suggesting that metformin per se could not exert protective effects via GLP-1R, instead, metformin upregulated GLP-1R to enhance the protective effects of liraglutide on endothelial function

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Lysosomal proteins are delivered either directly from the TGN to lysosomes via endosomes or indirectly via the plasma membrane (PM) through endocytosis

More serious but rare risks involve low blood sugar, gallstones, and pancreatitis