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While glutathione synthesis is controlled by multiple factors, GCL is the main determinant, because the rate-limiting step is the cellular level of the amino acid cysteine
in fact, poor tolerability was encountered in only 3.9% of patients, whereas 1.6% discontinued treatment due to treatment-related adverse events [46]
Baseline characteristics Both groups were broadly similar in terms of BMI, RA duration, and the use of conventional, biologic, or targeted synthetic disease-modifying antirheumatic drugs (DMARDs)
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