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Amino Acid Sequence# The primary sequence of retatrutide contains approximately 39 amino acid residues with the general structure: His-(Aib)-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2, with a C18 fatty diacid moiety conjugated through a linker at the Lys30 position

In the systemic circulation, endothelial dysfunction, detectable in healthy individuals with normal brachial blood pressure, is associated with increased central pulse pressure and systemic arterial stiffening

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