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However, the older subgroup without obesity, compared to the overall population, had a longer duration of diabetes (13 vs

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doi: 10.3389/fpsyt.2026.1782761 Received 07 January 2026 Revised 18 March 2026 Accepted 18 March 2026 Published 13 April 2026 Volume 17 - 2026 Edited by Octavian Vasiliu, Carol Davila University Emergency Military Central Hospital, Romania Reviewed by Ju-Tae Sohn, Gyeongsang National University Hospital, Republic of Korea Vibha K

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Second, the final maintenance dose may be lower than what you would use with retatrutide alone, because the cagrilintide component provides additional appetite suppression and metabolic benefit that reduces the need for maximum retatrutide dosing