The use of agents increasing GLP-1 receptor signaling may be associated with a neuroprotective effect in Alzheimers disease (AD) by preventing declines in cortical activity, decreasing A-levels and improving cognitive function as well as the volume of gray matter of patients
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GLP-1-GIP co-agonist tirzepatide was approved by the US Food and Drug Administration in 2022 for the treatment of T2DM (Nogueiras et al., 2023)
When performing an intention-to-treat analysis, the HR for MOF was found to be 0.89 [0.781.02] with GLP-1 RAs compared to DPP-4is, although this became significant in the fully adjusted model (HR 0.85 [0.74 0.98])
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The American Society of Anesthesiologists has issued specific guidelines around this