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The Epac2 arm activates PLC epsilon through Rap1 and this also leads to increased intracellular Ca 2+ ( Figure 3 )

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This issue can get better with time

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Insulated medication travel cases with reusable ice packs or cooling gel packs are effective for maintaining appropriate temperatures during travel

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Lithium and valproate also protect against mitochondria-mediated cell toxicity [58]

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After 30 days, discard any remaining solution regardless of how much is left

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Rosenfield RL et al

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