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Exendin-4, liraglutide and semaglutide can directly or indirectly stimulate POMC neurons in the ARC, while indirectly inhibiting NPY/AgRP neurons via presynaptic GABAergic neurons [82-84]
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The expression of genes for a series of antioxidant-related enzymes (-glutamylcysteine synthetase, GSH reductase, glutathione- S -transferase, GSH peroxidase, and superoxide dismutase) in diverse tissues was upregulated by these supplements [35]