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These data are consistent with the T allele decreasing risk for T2D, as well as decreasing glucose and HbA1c levels, but slightly increasing the risk of smoking initiation (Supplementary Table 16)

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However, it has become clear recently that immunoprecipitated and even recombinantly expressed and purified class IIa HDACs (eg, HDAC4) associate with class I HDACs and that these co-purifying enzymatic activities can occlude the true selectivity and potency of inhibitor treatments (Lahm et al, 2007