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SeckTNauckMShengDSungaSDaviesMJSteinPPet al
FP values from the competition assay were fitted (GraphPad Prism) to a sigmoidal dose-response equation where Y is the fluorescence polarization signal, B bottom is the FP value of FITC-labeled peptide in absence of protein, B amp is the amplitude of FP signal ( B top B bottom ), IC50 is non-labeled peptide concentration required for 50% apparent inhibition, X is the logarithmic value of non-labeled peptide concentration and nH is the Hill coefficient
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ABSTRACT Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated considerable efficacy in the treatment of diabetes and obesity, it is essential to recognize that their use is associated with certain intrinsic risks that must not be disregarded
10 CONCLUSION Here, JDD authors Samantha Ouellette, BA, Giulia Frias, BA, Radhika Shah, MD, PharmD, Mahin Alamgir, MD, and Cindy Wassef, MD report two cases of dermal hypersensitivity reactions to semaglutide
