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One possible explanation is that tirzepatide activates GIP receptors on GABAergic neurons in the nucleus tractus solitarius and area postrema, which are involved in anti-emetic mechanisms, thereby reducing the occurrence of nausea and vomiting [85, 86]
Two notable categories of underreported symptoms include reproductive issues, such as irregular menstrual cycles, and temperature-related complaints, including chills and hot flashes
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