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Br Med J 1970;3:557-8

Yes, generally

The evidence regarding why some patients experience persistent sugar cravings while others do not continues to evolve, with ongoing research examining these differences

In 1902, Bayliss and Starling identified secretin, the first gut hormone proof that the intestine sends chemical signals to other organs

Because they target the brains reward centre, the mesolimbic system, they apparently do not just stop food noise but inadvertently the quiet joy found elsewhere

Our low and slow dose escalation strategy is specifically designed to minimize these, but its important to know what to expect