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Semaglutide GLP-1 has several effects on the body that influence weight loss by promoting feelings of fullness and helping the body retain food for longer

These effects form the foundation of incretin-based obesity therapy and have been studied extensively since semaglutides approval in 2017

For example, combining tirzepatide with other GLP-1 receptor agonists is generally not recommended, as they have similar mechanisms of action and could lead to overlapping side effects

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Starting from a therapeutic dose of 15 mg weekly, the schedule uses the same four-week intervals between each dose reduction