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Commonly proposed CBD anticancer mechanisms include the increased production of reactive oxygen species (ROS), leading to cell death via autophagy, preventing the degradation of the endocannabinoid anandamide (AEA), which leads to the inhibition of fatty acid amide hydrolase (FAAH), as well as interactions with other types of receptors (GPR55, TRPV1, TRPV2, TRPM8) (ledziski et al., 2018
Liraglutide 3 mg (Saxenda) a once-daily GLP-1 receptor agonist licensed for obesity management (NICE TA664)
Ozturk, P., Kurutas, E., Ataseven, A., Dokur, N., Gumusalan, Y., Gorur, A., Tamer, L
In additional experiments, treatment of DIO rats with GEP12 at 10 nmol/kg/day resulted in significant reductions in food intake and body weight (food intake: mean difference 41.3 kcal/day, 95% CI 62.8 to 19.9 kcal/day, p = 0.0019
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