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The observation that the metabolic effects of GLP-1RA/tesaglitazar depend on functional GLP-1R in vivo align with our in vitro demonstration that GLP-1RA/tesaglitazar fails to induce PPAR/RXR heterodimerization in the absence of GLP-1R (Fig
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Knowing my kids feel goodand the dust has settled
It is a safe and effective treatment option for individuals suffering from type 2 diabetes
What survives that test is narrower and more testable than the broad claim it replaces: that brain-penetrant agonism, delivered early, in patients chosen by their biology rather than their diagnosis, and judged against biomarkers rather than questionnaires, might still work
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