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Health systems and clinicians should evaluate how these changes affect patient demand, prescribing patterns, and care coordination, while remaining alert to further guidance from CMS and the FDA as demonstration models unfold.

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With proactive monitoring and patient education, the benefits of GLP-1 therapy can far outweigh the risks

for example, tirzepatide and GLP-1 behave similarly at the mGLP-1R, whereas tirzepatide is less potent at the mGIPR than mGIP

As always, we recommend a consultation with a doctor to determine whether these treatments are suitable for you

Lancet, 398(10317), 2160-2172