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One recent analysis of six years of medical records from the Department of Veterans Affairs, which reviewed the records of 2 million patients with diabetes, found that those taking a GLP-1 agonist medication had a reduced risk of developing dementia, including Alzheimers, as well as psychiatric and substance use disorders, though it also found an increased risk of gastrointestinal disorders, kidney stones, and pancreatitis

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In general, a (pro)drug or nanocarrier administered by a specific route follows numerous pharmacokinetic processes such as absorption (with exception to intraarterial and intravenous administration), distribution, metabolism, and excretion (Fig

Interestingly, normal physiological levels of GLP-1 do not significantly stimulate metabolism, but prolonged elevation from receptor agonists can have a meaningful effect