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& Tapiero, H
Disruption of ERAD in this context impairs leptin responsiveness, resulting in hyperphagia, excessive weight gain, and heightened susceptibility to diet-induced obesity in mice
Most people tolerate berberine well, especially when taken with food
It helps keep the mean arterial pressure and heart rate to the normal baseline (7)
In vitro experiments found compound 31 (Figure 5) to be the most potent, as predicted by in-silico simulations, with an IC 50 of 3.16 M
The most common adverse events were gastrointestinal for both groups such as nausea, diarrhea, constipation, and vomiting
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