The downside is that the effects might be limited to appetite (and perhaps slower digestion) but not things like insulin release, since to affect blood glucose significantly, a GLP-1 mimic usually needs to reach the pancreas or induce hormones like insulin indirectly
Further, we did not detect significant changes in the protein levels of ETC complexes I to V and mitochondrial respiratory control ratio, during the ischemic phase or within 24 hours after reperfusion (Figure I in the online-only Data Supplement)
(2008) demonstrated that systemic administration of IGF-1 LR3 to dystrophic mdx mice (a model of Duchenne muscular dystrophy) significantly reduced susceptibility to contraction-mediated damage in extensor digitorum longus, soleus, and diaphragm muscles
Q: How long does Gl-Me GLP-1 Booster take to show results
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: Effects of homocysteine-lowering therapy
Like GLP-1, the GIP receptor likely responds to sustained exposure rather than requiring specific peak concentrations