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Efficacy determination was based on the effect of WEGOVY injection on resolution of steatohepatitis without worsening of liver fibrosis and on at least one stage improvement in liver fibrosis without worsening of steatohepatitis, on post-baseline liver biopsies collected at 72 weeks
Corona G, Maggi M
To achieve therapeutic semaglutide levels, the tablet must contain far more active ingredient than an injection
For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%
It works by mimicking the effects of the GLP-1 hormone, which helps regulate your blood glucose levels, digestion, and appetite
Unlike the consistent inhibition seen with GLP-1 analogues, Ex-4 has shown variable effects on adipogenic differentiation
