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Tumor risk via p53 pathway interference Mitigate risk by: Careful patient selection: exclude patients with pre-existing active malignancy or high tumour risk (e.g., known p53 mutations, familial cancer syndromes)

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Lancet 368(9544):13291338 Raymond E et al (2011) Sunitinib malate for the treatment of pancreatic neuroendocrine tumors

These types of fat can use energy and release some of that energy as heat