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Therefore, we evaluated the effect of the GLP-1R agonist, liraglutide, on cell GLP-1 production and PC1/3 expression using a tamoxifen-inducible cellspecific GLP-1RKO mouse model (9, 25)

BMC Family Practice, 22, 24

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But these are anecdotal observations, not clinical evidence, and they shouldnt be taken as a basis for changing treatment without medical guidance. Alcohol and other substance use disorders are common, but they remain substantially underdiagnosed and undertreated

Furthermore, the potential for this therapeutically desirable property was not suggested from the measurement of acute cAMP responses in CHO-GLP-1R cells, a standard in vitro metric for GLP-1R agonist performance in drug development 23 , where the more insulinotropic compounds displayed reduced potency vs