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Dysfunctions of AFG3L2 have been linked to neurodegenerative diseases such as dominant optic atrophy 33 and PINK1-mediated mitochondrial fission 34 , though its role in cancer remains under-investigated

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Conversely, in certain therapeutic contexts, lactate depletion strategies have been demonstrated to induce a synergistic activation of both apoptotic and ferroptotic pathways

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