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Anaphylaxis following a B12 injection has been documented in medical literature, particularly in patients with a sensitivity to cobalt or cobalamin compounds
Supplements are often needed
PMC 6611390
Direction of Future Research A multicenter randomized clinical trial is current in progress in Spain primary health-care setting called Project OB12 ( Conclusion Oral vitamin B12 replacement at 1000 g daily is an adequate alternative to IM B12 injections
For instance, vitamin B12 activates succinyl-CoA
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