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Phase 2 trial data published in 2023 showed participants receiving the highest retatrutide dose lost an average of approximately 24 percent of body weight over 48 weeks, which exceeded results seen with dual-agonist medications in comparable timeframes

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Use a controlled motion when you insert the needle and pull it out the same way

Modest elevations in resting heart rate were observed in the Phase 2 trial, which warrants monitoring in patients with pre-existing cardiovascular conditions

Effects of intensive blood-pressure control in type 2 diabetes mellitus

some protocols use up to 1000 mcg daily for more significant GI pathology