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Regulatory Toxicology and Pharmacology (2020) 12
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
This doesn't mean inject directly into the tendon or joint
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The free tripeptide GHK has a high affinity for divalent copper ions and exists in human plasma predominantly as the GHK-Cu complex
