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Cancer 8 (6), 10531061
139 Initially, it was hypothesized that the loss or reduction of ABCG2-mediated renal urate secretion would result in increased renal urate reabsorption, as diminished renal excretion is typically considered the primary mechanism of hyperuricemia in most gout patients
Then five to 10 years later, we started seeing vascular and cardiac issues
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It can affect anyone but is more common in people with asthma, with 3% to 10% of those with the condition potentially affected
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