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A new target for gold(I) compounds: glutathione-S-transferase inhibition by auranofin
Cardiovascular outcome trials for tirzepatide are ongoing, but the favorable effects on intermediate markers suggest probable long-term cardiovascular benefit
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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization
This step is so simple, yet it's often overlooked
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