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Although this study only featured the data from one person taking tirzepatide, it provides compelling data about how GLP-1 and GIP inhibitors alter electrical signals in the brain, said study co-first author Wonkyung Choi, a PhD candidate at the University of Pennsylvania School of Medicine in Philadelphia
Insulin resistance can also affect the balance of other hormones, such as leptin and ghrelin, which regulate appetite and satiety
Head-to-Head Superiority (SURMOUNT-5): The SURMOUNT-5 trial, with detailed results published in The New England Journal of Medicine on May 11, 2025, directly compared Tirzepatide (Zepbound) with semaglutide (Wegovy)
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