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Tirzepatide works by slowing stomach emptying and activating appetite-suppressing receptors in your brain, which can reduce thirst cues even as your body needs more fluid

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Autonomic Nervous System Effects: These medications are known to enhance sympathetic nervous system activity, which could influence optic nerve head perfusion, making the nerve more susceptible to ischemic damage

This is particularly relevant for patients with subclinical hypothyroidism who may have metabolic syndrome components