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In HEK293 cells expressing human GIP receptor or GLP-1 receptor, tirzepatide potently stimulated cAMP accumulation by both receptors, and the potency of tirzepatide was similar to that of native GIP and approximately 13-fold weaker than that of GLP-1 in these assays [88]

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doi: 10.7150/thno.29515 64 CaoJZhangXXuPWangHWangSZhangLet al

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As new GLP-1 receptor agonists enter the market for OSA treatment , pricing pressure may lead to more competitive reimbursement models and broader payer adoption