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The involvement of GLP-1 in PD can be simplified to the activation of the MAPK/extracellular signal-regulated kinase 1/2 (ERK) pathway, which has an important role in synaptic plasticity, and the PI3K/Akt pathway signaled by GLP-1 receptor stimulation and the subsequent increase in cAMP and PKA and PI3K activation [73]
doi:10.1007/s40199-018-0204-6CrossRefGoogle ScholarPubMed Madden, JM, Lakoma, MD, Lynch, FL, et al
It also dials down the release of glucagon, a hormone that raises blood sugar
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Combination therapy also likely lowers the risk of all-cause mortality and hospitalisation for heart failure
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