Real-Life Case Study: Sarahs Story (Composite example) Sarah, a 42-year-old Ottawa professional, came to my clinic complaining of chronic bloating, fatigue, and hangover headaches after healthy meals
Third, the optimal positioning and sequencing of GLP-1-based therapies relative to resmetirom and other emerging MASH agents (e.g., lanifibranor, pegozafermin, semaglutide combination regimens) requires dedicated combination trials, of which preliminary data from the MAESTRO-NASH secondary analysis are encouraging
The contemporary therapies, while associated with certain limitationsincluding difficulties with access, availability, and costpermit easier dosing, exhibit fewer side effects (especially hypoglycemia), and facilitate weight loss, with ever-increasing evidence of salutary effects across a spectrum of medical disease states (e.g., obstructive sleep apnea, kidney disease, CHF)
Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis
They may adjust your GLP-1 dose, modify other medications, or, in rare cases, consider discontinuing the GLP-1 agonist if the benefits no longer outweigh the risks
Institute of Medicine