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Citric acid cycle
Following the catabolism of glucose in the cytoplasm as part of glycolysis, the generated pyruvate is transported to the mitochondrial matrix, where it feeds into the TCA, undergoing oxidation to reduce NAD + to NADH, which is the main electron donor of the ETC 87
SLU-PP-332 is a small-molecule pan-ERR agonist with strongest potency at ERR that activates an exercise-like metabolic program in skeletal muscle, liver, and adipose tissue
Oxidative stress can contribute to fatigue and low energy levels
However, there is no outcomes-based evidence to support this recommendation
The infected mice exhibited a higher increase in interleukin (IL) IL-5, IL-4, and IL-2 than IL-12 and interferon- (IFN-), suggesting an important alteration in cytokine profile from Th1 to Th2 (Figure 2) [38]
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