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Meidenbauer JJ, Ta N, Seyfried TN
Recently, in addition to the central maintenance of food intake, GLP-1R signaling has begun to be considered in the context of the regulation of the stress response, as it is indicated that it can activate both the hypothalamicpituitaryadrenal (HPA) axis as well as the sympathetic nervous system [15, 16]
Perimenopause and menopause bring a combination of hormonal changes - declining oestrogen and progesterone, increased insulin resistance, shifts in fat distribution toward the abdomen that make weight management considerably harder than it was in earlier decades
However as far as the body is concerned, the process is unnatural and traumatic
Nausea and GI side effects, which are most common during dose escalation, can persist longer than with shorter-acting drugs because the drug clears slowly
Regular follow-up appointments are essential for monitoring progress and managing any adverse effects effectively
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