tirzepatide causes diarrhea and Mucus in Stool: and When to Seek Care explosive diarrhea tirzepatide The Link

Constipation occurs in some individuals due to slowed gastrointestinal transit, while others may experience loose stools or diarrhea

Lying down with a full stomach amplifies every GI side effect these medications can produce

Studies indicate that GLP-1R (glucagon-like peptide-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), and GCGR (glucagon receptor) act as crucial "regulators" in maintaining human blood glucose balance and are important therapeutic targets for type 2 diabetes and obesity

And neither does Williams

Blood work to measure serum magnesium is not routinely necessary unless you have kidney disease or are on multiple medications

The article adds that combined use has not been systematically studied for drug-drug interactions or cumulative adverse event rates, which is why it calls for extra clinical caution