Supplementation of bovine maturation media with thiol compounds is a useful tool for increasing the efficiency of embryo production in vitro, considering that the increased GSH produced during maturation can be maintained during the fertilization process and remain present at the beginning of embryo culture []
However, BSO induced cell death to a lesser extent with slower kinetics
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However, growing evidences in the last two decades suggest that GPx2 and GPx4 may also influence the cellular radiosensitivity in an organ-specific manner (Table 2) [54,55,56, 67]
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These metabolites spanned across five key classes: Carbohydrate Metabolomics, Nucleotide and Its Metabolites, Organic Acids and Derivatives, Phosphate Sugars, and Phosphoric Acids, suggesting a metabolic realignment in response to the redox disequilibrium induced by the absence of GR