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If you added 3mL instead of 2.5mL to a 50mg vial, your concentration is now 16.7mg/mL instead of 20mg/mL

Published clinical trials used continuous daily administration for 12-24 weeks without scheduled breaks, establishing this as a viable approach with maintained safety throughout the treatment period

However, their primary areas of celebrated efficacy differ, which is a key consideration when designing a study

Evidence from RCTs for the use of B12 in other types of neuropathies is scarce, although non-randomised/uncontrolled studies have shown some benefits

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A decrease in NAD+ adversely impacts cellular energy metabolism, while a reduction in SAM hinders the activation of genes that are vital for boosting metabolism