human postmortem spinal cord tissues have also shown similar deficits in TJ protein expression, particularly in the lumbar spinal cord regions, which are heavily affected by ALS pathology [215]
J Neuropathol Exp Neurol 71(10):840854 Krajewski D, Paul D, Ge S, Jellison E, Pachter JS (2021) Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE
Known causes include: Around one-third of people with diabetes (Type 1 or Type 2) develop gastroparesis
It's important to note that while these preclinical findings are compelling, human clinical trials remain limited
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