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Constipation: While less common than diarrhea, some patients report constipation as a side effect

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For affinity fusion proteins, the appended protein will bind to a third, typically small, molecule that is immobilized on the surface of a polymer resin

However, the relatively modest increase in ATP production (~22%) compared to the doubling of proton leak suggests that part of the respiratory activity may be uncoupled from ATP synthesis at the end of the study

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[57] This activation reduces the production of reactive oxygen species (ROS) and mitigates endoplasmic reticulum (ER) stress