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In scientific literature, NNMT is recognized as an enzyme that methylates nicotinamide (a precursor of NAD+) using S-adenosylmethionine (SAM) as the methyl donor, converting it to 1-methylnicotinamide (MNA) and potentially affecting cellular NAD+ availability
AOD-9604 is the modified 16-amino-acid version with an added N-terminal tyrosine that improves stability
High serum homocysteine levels may also be important in the pathogenesis of colon cancer, diabetic retinopathy, and other diseases
[Crossref] Andrs E, Dali-Youcef N, Vogel T, Serraj K, Zimmer J (2009) Oral cobalamin (vitamin B(12)) treatment
The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice
It plays a role in: Red blood cell formation: B12 is needed to produce healthy red blood cells, which carry oxygen throughout your body
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