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You might pause dose increases, return to a lower dose, or try switching to a different medication altogether

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Donal O Shea, specialist doctor in endocrinology and obesity management, explains the key things to know about retatrutide

Insulin blocks fat mobilization

Rather, its an eating approach designed to work alongside GLP-1 medications such as Ozempic, Wegovy, and Mounjaro

In vitro experiments showed that high glucose toxicity inhibited GLP-1 secretion by enteroendothelial cells and suppressed -catenin and TCF7L2 levels, suggesting an important role for TCF4 (TCF7L2) in glucose homeostasis and type 2 diabetes development (Shen et al., 2020