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Acute lower GI bleeding can also result from polypectomy and other similar therapeutic interventions

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The primary endpoint was change in HbA 1c at 26 weeks

Joint pain has also been reported by some users, particularly at higher doses

Evidence has demonstrated that iron deposition occurs in the brains of migraine patients ( Topiramate has been proposed as a migraine preventive medication because it inhibits ferroptosis via the glutathione peroxidase 4 (GPX4), GSH, and cystine/glutamate antiporter (System Xc-)