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This cycle has not been repeated according to the available research
87 A related principle may also operate in inflammatory tissue niches, where oxidized lipids, often associated with lipoprotein particles such as low-density lipoprotein (LDL), are cleared by resident immune cells, thereby modulating local ferroptotic thresholds and potentially influencing the permissiveness of propagation
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Cohort entry was defined as the date of the first-ever prescription for one of the drugs of interest (GLP-1RAs, SGLT2 inhibitors, metformin or other second- or third-line glucose-lowering drugs) during the study period, and their respective first exposure was defined as the index event
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