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This is one reason why nutritional guidance is an important component of a comprehensive weight loss program

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Average weight loss after 48 weeks included: 1 mg dose: about 8.7% body-weight reduction 4 mg dose: about 17.1% reduction 8 mg dose: about 22.8% reduction 12 mg dose: about 24.2% reduction Placebo: about 2.1% reduction These results represented one of the largest average weight reductions reported for an antiobesity medication in a randomized clinical trial

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Life Sci 65(9):849856 Weinshilboum RM (1989) Catecholamine biochemical genetics