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In conclusion, while both semaglutide and tirzepatide offer significant benefits in managing type 2 diabetes and weight loss, the decision to switch between these medications should be based on individual patient needs and guided by healthcare provider expertise

Our findings show that the magnitude of this treatment effect with semaglutide is independent of the amount of weight lost, suggesting that the drug has other actions which lower cardiovascular risk beyond reducing unhealthy body fat

The break period is not a return to pre-protocol habits but a period of peptide cessation while maintaining supportive behaviors

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