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PMID 10499368
Slowing the Gastric Rhythm: By slowing down food movement through the stomach, GLP-1 extends the time it takes for the body to process nutrients
It is approved to reduce excess abdominal fat in adults with HIV who have lipodystrophy, a condition in which excess fat develops in different areas of the body, particularly the liver and stomach
Safety protocols also include education on expected side effects, dose escalation plans to improve tolerability, and referral pathways if in-person care or urgent evaluation becomes necessary
Some discontinued clinical trials (for example in postoperative ileus) failed to demonstrate sufficient efficacy in primary endpoints, although certain biological signaling effects remained measurable and scientifically relevant
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